Unternavigation im Bereich: The Procedure

Answers to Frequently Asked Questions

We constantly receive questions regarding the Ruma Marker System and its handling in the clinical practice. This section gives you answers for the relevant questions, which were addressed to us in the past. We hope that you can also contribute towards the understanding of our method.

If you have any questions, which are not answered here, please get in touch with us.

What do the patients do in the waiting period?

This is organised by our colleagues differently: some of them use the waiting period for a physical examination or a therapy discussion. Others allow the patients to take care of personal things. Psychiatric facilities prefer to administer the market in the evenings so that the patient can collect the sample during the night or early morning (morning urine) independently and without any supervision.

Does heavy drinking of fluids before intake and during waiting period falsify the results?

Thumb rule: one litre of water dilutes the urine by a factor 10. The concentration of the marker falls below the Cut Off before the drugs become negative. Many colleagues evaluate strongly diluted urine like an attempt to cheat. Due to quality reasons, we always measure the urine-creatinine concentration to prove such cheating.

It is best to let the patients go to the toilet before administering the marker. This will ensure that the bladder is empty and the patients can also maintain the required 30 minutes.

How about the diabetics?

Even controlled diabetics can intake the marker in a beverage sweetened with household sugar.
If the test subject want to forego sugar, it is also possible. However, in this case please ensure that the marker is not collected with a sponge or similar and then included into clean urine. Have the subjects rinse their mouth multiple times once the marker has been imbibed. And please do not forget to note the lack of sugar intake in the laboratory card.

What is the significance of household sugar?

Household sugar is absorbed in the body and normally does not leave traces in urine. However, if it is detected in urine, it means that the marker has not been imbibed, but it was spit into the urine from other sources that was brought by the patient. For this purpose, a wad of cotton or foam is hidden in the mouth. Therefore, let the patient rinse the mouth thoroughly, if sugar has to be dispensed with in exceptional cases.

The mechanism of the marker is not hindered by sugar.

What is the cost of marker process for insurance patients?

In case of insurance patients, the marker analysis through laboratory referral is directly charged by us to the insurance provider. Therefore, insurance patients do not have to bear costs for the attending physician.

What are the suitable beverages?

All beverages, which have 150 g household sugar per litre, are suitable. Fruit tea or water has proven to be very useful. Additional 150 g of household sugar per litre must be added to all types of lemon juices or other juices in addition to the already existing sweeteners in the juices.
This is also applicable for classic Coca Cola listed by us already. Here the recipe has been changed so much that it no longer contains sufficient amount of household sugar.

Is this a medicine?

No. The polyethylene glycols used by us are neither medicines nor medicinal products nor diagnostic material. This has been confirmed by various agencies at international level. You can find our certificate of clearance as well as corresponding communication e.g. from EMA or FDA/CDER in the download centre.

Are there any side effects?


When will the marker be excreted completely?

In general, the marker is completely flushed out after 6 to 8 hours. If the patient cannot urinate in the meantime, the marker will remain in urine. Always use only the first urine sample after administering the marker.

How is the marker stored?

Just stored it at room temperature in closed condition. The marker freezes when cooled, but it can be thawed easily by just heating it up in the hand.

Can the marker get spoiled?


How do I store the sample?

For long-term storage (above 10 hours), we recommend storage in a refrigerator. However, the marker will remain unchanged even if it stored for weeks and months at room temperature, but the evidence of drugs can be disturbed by bacterial growth.

What is the duration for urine samples for later confirmation analyses?

In general, two weeks. Even longer storage periods are possible after you discuss it with the partner laboratory responsible for you.

How long can the marker be used as evidence?

If a longer storage period has been agreed, our partner laboratory will freeze the sample. In this case, the marker can be used any time as evidence.

What are the possible ways of manipulating the marker?

We have experienced two relevant types of manipulation attempts:
1). Mixing up the samples of marked urine
2). “Body Bypass”

Re. 1): We give different markers so that the patients do not mix “marked urine” or can buy it.

Re. 2): Some drug addicts keep a sponge in the mouth when they drink the marker fluid, which absorbs the marker so that they can spit it later into the “clean” urine they have brought along. We can easily detect this, because we give the marker in heavily sweetened fluids (fruit tea etc.) and saccharin is normally not present in urine. We test the urine sample for saccharine. Any possible addition of substances that destroy sugar such as yeast is also captured analytically.