No mo­re Doubts.

En­joy Se­cu­ri­ty and Ef­fi­ca­cy in­s­tead: The­ra­py Ad­he­rence 4.0

The di­gi­tal block­chain-ba­sed the­ra­py ma­nage­ment sys­tem for the me­di­cal prac­ti­ce


How an App makes a suc­cess­ful sys­tem mo­re user fri­end­ly, mo­re ef­fici­ent and mo­re re­lia­ble and ma­na­ges to an­nul the en­ti­re ad­he­rence pro­blem.

Ruma GmbH specializes in adherence support in the field of addiction therapy.

The patented Ruma Marker-System replaces the degrading direct observation of urine sample collection with marker substances. They allow the reliable matching of sample and sample donor.

Our extensive experience in this field serves as the ideal prerequisite to match the analog process to its digital counterpart.

We have trans­fer­red this ana­log pro­cess chain in­to the di­gi­tal world by re­pre­sen­ting the in­di­vi­du­al mar­ker sub­s­tan­ce as a di­gi­tal twin in a pri­va­te block­chain.

Now the di­gi­tal twin do­cu­ments the path of the sub­s­tan­ce from pro­duc­tion to dis­tri­bu­ti­on to the phy­si­ci­an, to the pa­ti­ent ta­king the sub­s­tan­ce, to va­li­da­ti­on of the uri­ne sam­ple by the lab, and fi­nal­ly to bil­ling.


For mo­re in­for­ma­ti­on plea­se download our

Information for Patients and our Flyer Ruma Digital System.



De­di­ca­ted to this new field of ap­pli­ca­ti­on, we de­ve­lo­ped a new form of ad­mi­nis­tra­ti­on for the tried and tested Ru­ma Mar­kers - the Ru­ma Cap­su­le!

Cle­an, ea­sy to ap­ply, and re­ady to use wit­hout fur­ther pre­pa­ra­ti­on.


Mul­ti­laye­red se­cu­ri­ty fea­tures on se­con­da­ry and pri­may pa­cka­ging are ve­ri­fied by the app to pro­tect against sub­sti­tu­ti­on of the in­di­vi­dual­ly mar­ked cap­su­le.


To do so, we are using the gui­de­li­nes and re­com­men­da­ti­ons of the EU Fal­si­fied Me­di­ci­nes Di­rec­ti­ve 2011/62/EU in or­der to in­te­gra­te the Ru­ma Mar­ker-Sys­tem even mo­re smooth­ly in­to the health ca­re sys­tem.


The cap­su­le its­elf con­tains, in ad­di­ti­on to the mar­ker sub­s­tan­ces them­sel­ves ,a blue dye that per­forms the job of the su­gar with the li­quid mar­kers: the cap­su­le dis­sol­ves in the mouth if not swal­lowed in a ti­me­ly man­ner, re­leasing the dye and co­lo­ring the oral ca­vi­ty blue. This way, at­tempts to not ac­tual­ly swal­low the cap­su­le be­co­me im­me­dia­te­ly and re­lia­b­ly vi­si­ble.

Ab­so­lu­te­ly re­lia­ble


Wir ha­ben die neue Dar­rei­chungs­form wis­sen­schaft­lich über­prü­fen las­sen. Die Stu­die zur Aus­schei­dungs­ki­ne­tik be­legt, dass auch hier die Mar­ker zu 100% im La­bor de­tek­tiert wer­den. Die War­te­zeit bis zur Ab­ga­be der Urin­pro­be be­trägt für die Kap­sel 60 Mi­nu­ten.

Die voll­stän­di­gen Stu­di­en­ergeb­nis­se kön­nen Sie hier her­un­ter­la­den. We had the new form of ad­mi­nis­tra­ti­on tested in a sci­en­ti­fic stu­dy. This stu­dy on ex­cre­ti­on ki­ne­tics de­mons­tra­tes that this form as well has a la­bo­ra­to­ry de­tec­tion ra­te of 100%. Using the cap­su­le the wai­ting pe­ri­od un­til the uri­ne sam­ple can be collec­ted is 60 mi­nu­tes.


You can down­load the com­ple­te re­sults of the stu­dy he­re.


Con­ve­ni­ent and Lo­ca­ti­on-In­de­pen­dent


Whe­ther at home or on the go - App and cap­su­le can be used any time. In to­tal pri­va­cy. Vi­si­ting your health ca­re pro­vi­der is on­ly ne­cess­a­ry to crea­te the in­iti­al link bet­ween sam­ple collec­tor and sam­ple do­nor.

Why Block­chain in a Medical App?

We use block­chain tech­no­lo­gy to en­su­re se­cu­re da­ta trans­fer. It is the car­ri­er of all in­for­ma­ti­on:


  • re­gar­ding the samp­les and their life cy­cle
  • re­gar­ding the sam­ple do­nors
  • re­gar­ding sam­ple collec­tors and their re­spec­ti­ve fa­ci­li­ties

Plus, the history of the data is stored in their "life cycle" including all changes, administrative activities and protocols.

Every change can be traced back to a specific user so that these data are unforgeable and unchangeable. Data storage on the blockchain is audit-proof.

The Consultation that doesn‘t require an Appointment.

The physician can check the digital recording of the patient's marker intake at his or her convenience. No need for trips to the medical office or waiting times. But instead more freedom for optimized office procedures.

After the intake process has been recorded the sample collector is notified accordingly.

He or she can now watch and check the video. The video is assessed by means of a defined scale that differentiates between „Successful Intake“ "Failed Attempt" or „Manipulation Attempt“.

Are you interested in the digital version of the ruma marker-system?