The Ruma Marker-System is more than just the search for the administered marker. We use 4 pillars to test the urine samples for manipulation from all perspectives:

• Marker analysis
• Creatinine analysis
• Glucose analysis
• Sample integrity analysis
• Analysis for synthetic urine

The Marker Analysis determines whether the urine sample contains the administered marker and whether it is present in sufficient quantity. Complete absence of the marker is an indication of sample substitution. Very little marke volume suggests dilution. This applies to dilution with “clean” urine as well.

The Creatinine Analysis examines the dilution level of the urine sample. There is a certain association between creatinine contents and marker contents when our system is used. Now, if urine is diluted with urine and creatinine content should actually be ok, we will discover this form of manipulation through this tie.

The Glucose Analysis ensures that the marker has actually been ingested by the patient and not spat or otherwise brought into a urine sample originating from another person. 
The co-administered household sugar is normally metabolized by the body and should not be found in the urine sample. If household sugar is indeed found in the urine, one of the following explanations may apply:

• Body Bypass, i.e. the marker was not actually ingested by the patient
• The patient is suffering from diabetes
• Methadone was not ingested but injected.
   

The Sample Integrity Analysis tests the urine sample for possible chemical manipulations including pH-value measurement and test for oxidants.

The detection of synthetic urines is also part of the patented Ruma® Marker-System.

The analyses we defined mesh with each other and reliably detect manipulations.